SCI
14June
NeoadjuvantImmunotherapyforNon-SmallCellLungCancer-CurrentConceptsandFutureApproaches
DipeshUprety,SumithraJ.Mandrekar,DennisWigleetal.NeoadjuvantImmunotherapyforNon-SmallCellLungCancer-CurrentConceptsandFutureApproaches.[J].JThoracOncol,,undefined:undefined.
Abstract摘要
Lungcanceristheleadingcauseofcancer-relateddeathsworldwide.Patientswithresectablenon-smallcelllungcancer(NSCLC)areoftentreatedwithsurgeryandadjuvantchemotherapy.However,thesepatientscontinuetohaveahighriskofrecurrenceanddeath.Unfortunately,therehasbeenlittleprogressinthetreatmentofresectableNSCLCoverthelastseveraldecades.Neoadjuvanttherapy,whichhasbeenconsideredanapproachtoimprovesurvivalforresectableNSCLCpatients,isahotlydebatedtopic.Asystematicreviewof32randomizedtrialsinvolving10,patientsdemonstratedthattherewasnodifferenceinsurvivalbetweenpreandpost-operativechemotherapy.Becauseofsuchresults,andthetheoreticalconcernaboutresectabletumorsprogressingonrelativelyineffectiveneoadjuvantchemotherapyandthusbe
